反応 #6590

反応方程式

4-ethoxybenzyl alcohol

3-hydroxybenzaldehyde

triphenylphosphine

→

3-(4-ethoxybenzyloxy)benzaldehyde

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   濃縮Concentrate the solution in vacuo
2. 2
   workup.ADDITIONdilute with a small quantity of ethyl ether
3. 3
   ろ過Filter any precipitate
4. 4
   濃縮concentrate the filtrate in vacuo
5. 5
   その他Purify by silica gel chromatography

実験手順

Mix 4-ethoxybenzyl alcohol (3.35 g. 22 mmol), 3-hydroxybenzaldehyde (2.69 g, 22 mmol), triphenylphosphine (5.8 g, 22 mmol) and diethylazadicarboxylate (3.83 g, 22 mmol) in tetrahydrofuran (25 mL). Stir at room temperature under anhydrous atmosphere until the reaction is done. Concentrate the solution in vacuo and dilute with a small quantity of ethyl ether. Filter any precipitate and concentrate the filtrate in vacuo. Purify by silica gel chromatography to give 3-(4-ethoxybenzyloxy)benzaldehyde.

出典