反応 #65816

反応方程式

2-bromooctanoic acid

thionyl chloride

→

2-bromooctanoyl chloride

収率 64.0%

溶媒

toluene

反応条件

後処理

1. 1
   温度The solution was heated
2. 2
   温度at reflux under nitrogen for 3 hours
3. 3
   workup.DISTILLATIONThe excess thionyl chloride and toluene were distilled at atmospheric pressure under N2
4. 4
   workup.DISTILLATIONThe yellow residue was purified by kugelrohr distillation (bp=60°-65° C./0.1 mm Hg)

実験手順

To a solution of 20 g (90 mmol) 2-bromooctanoic acid in 100 mL toluene was added 13.2 mL (180 mmol) thionyl chloride. The solution was heated at reflux under nitrogen for 3 hours. The excess thionyl chloride and toluene were distilled at atmospheric pressure under N2. The yellow residue was purified by kugelrohr distillation (bp=60°-65° C./0.1 mm Hg) and 13.8 g (64%) of the 2-bromooctanoyl chloride as a colorless oil was isolated.

出典