反応 #6578

反応方程式

n-butylimidazole

sodium hydride

2-chloro-6-fluorobenzylchloride

→

2-n-butyl-1-(2-chloro-6-fluorophenyl)methyl-1H-imidazole

収率 95.3%

溶媒

—

ice water

dimethylformamide

dimethylformamide

dimethylformamide

反応条件

後処理

1. 1
   workup.STIRRINGThe mixture was stirred for 17 hours at ambient temperature
2. 2
   抽出extracted with ethyl acetate
3. 3
   その他The washed, dried

実験手順

A solution of 2 n-butylimidazole (3.75 g, 0.03 mol) in dry dimethylformamide (4 ml) was added to sodium hydride (0.95 g) in dimethylformamide (18 ml). After the gas evolution subsided, the mixture was stirred one hour under argon and 2-chloro-6-fluorobenzylchloride (5.5 q, 0.031 mol) in dimethylformamide (7 ml) was added slowly. The mixture was stirred for 17 hours at ambient temperature, diluted with ice water and extracted with ethyl acetate. The washed, dried, concentrated organic layer provided 7.63 g (94%) of 2-n-butyl-1-(2-chloro-6-fluorophenyl)methyl-1H-imidazole whose NMR was consistent with the structure. This material was used without further purification.

出典