反応 #65738

反応方程式

3,6-Epoxy-3-ethoxy-4,5-dimethoxycarbonyl-2-phenyl-3,4,5,6-tetrahydropyridine

hydrazine monohydrate

water

→

8-Hydroxy-7-phenylpyrido[3,4-d]pyridazine-1, 4(2H, 3H)-dione

溶媒

acetic acid

反応条件

後処理

1. 1
   温度Under ice-cooling
2. 2
   ろ過The resulting yellow crystalline precipitate was recovered by filtration

実験手順

3,6-Epoxy-3-ethoxy-4,5-dimethoxycarbonyl-2-phenyl-3,4,5,6-tetrahydropyridine (500 mg; 1.5 mmol) was added to hydrazine monohydrate (5 ml), and the mixture was heated in a stream of nitrogen at 100° C. for 1 hour. Under ice-cooling, water was added to reaction mixture, and the mixture was neutralized with acetic acid. The resulting yellow crystalline precipitate was recovered by filtration. Yield: 210 mg (55.0%).

出典