反応 #65735

反応方程式

5-(trifluoromethyl)-5-methylpyrrolidin-2-one

triethylamine

anisoyl chloride

→

N-(4-methoxyphenylcarbonyl)-5-(trifluoromethyl)-5-methylpyrrolidin-2-one

溶媒

dioxane

反応条件

後処理

1. 1
   その他The solid which precipitates
2. 2
   ろ過is filtered off with suction
3. 3
   洗浄the salt is washed with a little dioxane
4. 4
   その他the organic phase is separated off with the addition of a little methylene chloride
5. 5
   その他is recrystallized from ligroin

実験手順

5.0 g (0.03 mol) of 5-(trifluoromethyl)-5-methylpyrrolidin-2-one in 10 ml of dioxane are stirred with 3.3 g of triethylamine and 6.8 g (0.04 mol) of anisoyl chloride for 16 h at 110°-120° C. The solid which precipitates is filtered off with suction and the salt is washed with a little dioxane. The dioxane solution is stirred into 50 ml of water and the organic phase is separated off with the addition of a little methylene chloride. After stripping off the solvent, the residue is a brownish solid which is recrystallized from ligroin.

出典