反応 #657326

反応方程式

4-(2-phenylpyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-amine

sodium borohydride

water

→

4-(2-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-amine

収率 49.8%

溶媒

ethanol

反応条件

後処理

1. 1
   抽出extracted with dichloromethane (3×50 mL)
2. 2
   乾燥dried over anhydrous magnesium sulphate
3. 3
   ろ過filtered
4. 4
   濃縮concentrated under reduced pressure

実験手順

To a mixture of 4-(2-phenylpyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-amine (60 mg, 0.2 mmol, 1 eq) in 3 mL of ethanol is added sodium borohydride (17 mg, 0.45 mmol, 2.2 eq). The mixture is stirred at room temperature for 2 h. The mixture is then poured into water, extracted with dichloromethane (3×50 mL), dried over anhydrous magnesium sulphate, filtered and concentrated under reduced pressure. 29 mg (47%) of 4-(2-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl)pyridin-2-amine are obtained as a white solid which is used in the next step without further purification.

出典