反応 #657307

反応方程式

methyl 3-(4-fluorophenyl)-3-oxopropanoate

hydrazine hydrate

diethyl ether

→

3-(4-fluorophenyl)-1H-pyrazol-5-ol

溶媒

acetic acid

反応条件

後処理

1. 1
   温度is heated 3 h
2. 2
   温度under reflux
3. 3
   温度The resulting suspension is cooled down
4. 4
   ろ過The precipitate is filtered off
5. 5
   乾燥dried in vacuo and 9 g (100%) of 3-(4-fluorophenyl)-1H-pyrazol-5-ol
6. 6
   その他are obtained as white solid

実験手順

A mixture of methyl 3-(4-fluorophenyl)-3-oxopropanoate (10.0 g, 0.051 mol) and hydrazine hydrate (1.1 eq, 2.8 g, 0.056 mol) in 20 mL glacial acetic acid is heated 3 h under reflux. The resulting suspension is cooled down and 10 mL diethyl ether is added. The precipitate is filtered off, dried in vacuo and 9 g (100%) of 3-(4-fluorophenyl)-1H-pyrazol-5-ol are obtained as white solid.

出典