反応 #657296

反応方程式

Triethylamine

D-(+)-Ribonic acid gamma-lactone

methanol

3-Hydroxytyramine

→

dopamine ribonamide

収率 188.1%

溶媒

acetone

反応条件

後処理

1. 1
   workup.DISSOLUTIONuntil dissolved
2. 2
   その他an additional 5 min
3. 3
   workup.DISSOLUTIONto dissolve
4. 4
   workup.STIRRINGwith stirring, over the course of about 10 minutes
5. 5
   温度the reaction mixture refluxed for 4 hr
6. 6
   その他Solvents were removed by rotary evaporation
7. 7
   その他to remove any residual water
8. 8
   その他(1 hr.)
9. 9
   その他to give a white solid
10. 10
    その他again resulting in a white solid as a product
11. 11
    ろ過The resultant solid was collected by filtration
12. 12
    その他dried in vacuo for 6 hrs

実験手順

D-(+)-Ribonic acid gamma-lactone (2.0 gm, 13.5 mmol) was added to methanol (25 mL) in a 100 mL round bottom flask with stirring until dissolved, and then an additional 5 min. 3-Hydroxytyramine (2.6 gm, 13.5 mmol) was added slowly, allowing it to dissolve, with stirring, over the course of about 10 minutes. Triethylamine (1.4 gm, 13.5 mmol) was then added and the reaction mixture refluxed for 4 hr. in the dark, during which time the solution acquired a slight yellow color. Solvents were removed by rotary evaporation using anhydrous ethanol as an azeotrope to remove any residual water. The resultant dried product constituted a thick syrup which solidified upon standing (1 hr.) to give a white solid. The white solid product was stirred (1 hr.) with acetone (40 mL), again resulting in a white solid as a product. The resultant solid was collected by filtration and dried in vacuo for 6 hrs. yielding dopamine ribonamide (3.83 gm, 12.7 mmol, 94.1% yield.) 1H and 13C-NMR results and CHN analyses were consistent with structure. Melting point was 90-91° C. Predicted C13H19N1: (301.30): C, 51.82; H, 6.36; N, 4.65; Analysis results of synthesis product: C, 51.67; H, 6.40; N, 4.69.

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