反応 #657257

反応方程式

1-trityl-4-ethoxymethylpyrazole

→

4-ethoxymethylpyrazole

収率 44.0%

溶媒

ethanol acetone

HCl

反応条件

後処理

1. 1
   workup.ADDITIONwas added to the resulting solution
2. 2
   温度After cooling to room temperature
3. 3
   ろ過the reaction mixture was filtered
4. 4
   洗浄washed with dichloromethane
5. 5
   抽出extracted with dichloromethane
6. 6
   乾燥dried over MgSO4
7. 7
   その他the solvent was evaporated under vacuum

実験手順

1-trityl-4-ethoxymethylpyrazole (1.800 g, 4.88 mmol) was dissolved in a mixture of ethanol/acetone (15 ml/5 ml) and 30 mL of 2N HCl was added to the resulting solution. The mixture was heated at 80° C. for 2 h. After cooling to room temperature, the reaction mixture was filtered and washed with dichloromethane. The aqueous layer was basified with 2N NaOH and extracted with dichloromethane. The organic layers were combined, dried over MgSO4 and the solvent was evaporated under vacuum yielding compound 4-ethoxymethylpyrazole as a white oil. Yield: 44% (270 mg, 2.14 mmol).

出典