反応 #657255

ord-43ed1bcb2315415481cb713c6d8ab10b

反応方程式

OCc1cnn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c1
1-trityl-4-hydroxymethylpyrazole
[H-].[Na+]
sodium hydride
CI
iodomethane
COCc1cnn(C(c2ccccc2)(c2ccccc2)c2ccccc2)c1
1-trityl-4-methoxymethylpyrazole
収率 93.0%

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他This compound is obtained

実験手順

This compound is obtained by reacting 1-trityl-4-hydroxymethylpyrazole (555 mg; 1.63 mmol) in dry tetrahydrofuran with sodium hydride (98 mg; 2.44 mmol) and iodomethane (0.5 mL; 8.15 mmol). Yield: 93% (536 mg, 1.51 mmol).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US09023315B2uspto-grants-2015_05