反応 #65723

反応方程式

6-Chloronicotinic acid

hydrazine hydrate

→

pale brown solid

収率 77.0%

6-Hydrazinopyridine-3-Carboxylic Acid

収率 77.0%

溶媒

water

hydrochloric acid

反応条件

後処理

1. 1
   その他was placed in a 100° C.
2. 2
   その他for 4 hours
3. 3
   濃縮The homogeneous reaction mixture was concentrated to dryness
4. 4
   その他to give a white solid
5. 5
   その他formed
6. 6
   その他The precipitate was isolated by filtration
7. 7
   洗浄the solid was washed with 95% ethanol and ether

実験手順

6-Chloronicotinic acid (8.0g) was added to 85% hydrazine hydrate (35 ml). The reaction mixture was placed in a 100° C. oil bath for 4 hours. The homogeneous reaction mixture was concentrated to dryness to give a white solid. The solid was dissolved in water and on acidification to pH 5.5 with concentrated hydrochloric acid a precipitate formed. The precipitate was isolated by filtration and the solid was washed with 95% ethanol and ether to give 6.0 g of a pale brown solid; yield 77% m.p. 292°-293° C.;

出典