反応 #6566

反応方程式

KOH

ethanol

dibenzyl 2-(3,4,4-trifluoro-3-butenyl)-malonate

→

2-(3,4,4-Trifluoro-3-butenyl)malonic acid

溶媒

water

water

反応条件

後処理

1. 1
   温度After heating
2. 2
   温度under reflux for 4 hours
3. 3
   洗浄washed with ether
4. 4
   抽出extracted 4 times with ether
5. 5
   乾燥The organic phase was dried over sodium sulphate
6. 6
   ろ過filtered
7. 7
   濃縮concentrated in a rotary evaporator

実験手順

5.56 g (99 mmol) KOH flakes were dissolved in 6.82 ml water and 13.65 ml ethanol and then treated with 11.12 g (28.34 mmol) of dibenzyl 2-(3,4,4-trifluoro-3-butenyl)-malonate. After heating under reflux for 4 hours, the reaction mixture was poured into 30 ml water and washed with ether. The aqueous phase was acidified with dilute hydrochloric acid and extracted 4 times with ether. The organic phase was dried over sodium sulphate, filtered and then concentrated in a rotary evaporator.

出典