反応 #65645

反応方程式

cyclohexylamine

atropic acid

N-methylmorpholine

iso-butyl chloroformate

→

product

収率 28.9%

N-Cyclohexyl-2-phenylpropenamide

収率 28.9%

反応条件

後処理

1. 1
   その他The crude product was purified by recrystallisation from cyclohexane

実験手順

This compound was made from atropic acid (10.48 g, 70.8 mmol), N-methylmorpholine (7.8 ml, 70.9 mmol), iso-butyl chloroformate (9.2 ml, 70.9 mmol), and cyclohexylamine (8.1 ml, 70.7 mmol) using the procedure described in Example 3. The crude product was purified by recrystallisation from cyclohexane to give the product (4.69 g), as white crystals, m.p. 131°-133°. (Found: C, 78.7; H, 8.8; N, 5.95. C15H19NO requires C, 78.6; H, 8.35; N, 6.1%.)

出典