反応 #655969

反応方程式

(S)-2-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]-1-propanol hydrochloride

thionyl chloride

→

(S)-N-(2-chloro-1-methylethyl)-3,4-dimethoxy-N-methylbenzeneethaneamine hydrochloride

収率 43.0%

溶媒

chloroform

反応条件

後処理

1. 1
   温度the reaction was heated
2. 2
   温度to reflux for 3 hr
3. 3
   温度The reaction was cooled
4. 4
   その他the solvent was evaporated in vacuo

実験手順

To a solution of 7.06 g (0.028 mole) of (S)-2-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]-1-propanol hydrochloride in 100 ml of chloroform was added 4.8 ml (0.067 mole) of thionyl chloride and the reaction was heated to reflux for 3 hr. The reaction was cooled and the solvent was evaporated in vacuo to give 3.09 g of (S)-N-(2-chloro-1-methylethyl)-3,4-dimethoxy-N-methylbenzeneethaneamine hydrochloride as a brown glass (43%).

出典