反応 #65482

ord-87177dc4843a45a081558e110fdea74d

反応方程式

CCCCC#CC(=O)c1ccc(Br)cc1
product
CCCCC#CC(=O)c1ccc(Br)cc1
1-(4-bromophenyl) 2-heptyn-1-one
Cc1cc(C)c(S(=O)(=O)[O-])c(C)c1.N[n+]1ccccc1
N-aminopyridinium mesitylene sulfonate
O=C([O-])[O-].[K+].[K+]
potassium carbonate
→
CCCCc1nn2ccccc2c1C(=O)c1ccc(Br)cc1
(4-bromophenyl) (2-butyl pyrazolo(1,5-a) pyridin-3-yl) methanone

反応物

CCCCC#CC(=O)c1ccc(Br)cc1
product
CCCCC#CC(=O)c1ccc(Br)cc1
1-(4-bromophenyl) 2-heptyn-1-one
Cc1cc(C)c(S(=O)(=O)[O-])c(C)c1.N[n+]1ccccc1
N-aminopyridinium mesitylene sulfonate
O=C([O-])[O-].[K+].[K+]
potassium carbonate

試薬

なし

溶媒

CC#N
acetonitrile
CC#N
acetonitrile

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

A mixture of 2.5 g of N-aminopyridinium mesitylene sulfonate (prepared by Synthesis, 1977 page 1, TAMURA, et al.), 25 ml of acetonitrile and 3.5 g of potassium carbonate was stirred for 15 minutes at ambient temperature and then the 2.27 g of the product of Step A in solution in 25 ml of acetonitrile were added.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US05420138uspto-grants-1995_05