反応 #65389

反応方程式

2-(6-amino-3,4-dihydro-2,2-dimethyl-2H-1,4-benzoxazin-4-yl)pyridine N-oxide

acetic anhydride

→

2-(6-acetamido-3,4-dihydro-2,2-dimethyl-2H-1,4-benzoxazin-4-yl)pyridine N-oxide

反応条件

後処理

1. 1
   濃縮After concentration
2. 2
   workup.DISSOLUTIONthe residue was dissolved in chloroform
3. 3
   洗浄washed with saturated aqueous sodium hydrogen carbonate solution
4. 4
   その他dried
5. 5
   濃縮concentrated
6. 6
   その他The residue was recrystallized from chloroform-ether

実験手順

To a solution of 0.474 g of 2-(6-amino-3,4-dihydro-2,2-dimethyl-2H-1,4-benzoxazin-4-yl)pyridine N-oxide in 5 ml of acetic anhydride was added 3 drops of pyridine and the mixture was stirred at room temperature for 63 hours. After concentration, the residue was dissolved in chloroform, washed with saturated aqueous sodium hydrogen carbonate solution, dried and concentrated. The residue was recrystallized from chloroform-ether to give 0.285 g of 2-(6-acetamido-3,4-dihydro-2,2-dimethyl-2H-1,4-benzoxazin-4-yl)pyridine N-oxide.

出典