反応 #653655

反応方程式

5-acenaphthylamine

triethylamine

4-tert-butylbenzyl-bromide

→

N-(5-acenaphthyl)-4-tert-butylbenzylamine

溶媒

toluene

反応条件

後処理

1. 1
   workup.STIRRINGThe reaction mixture was stirred at 23° C. for 15 hours
2. 2
   その他precipitates
3. 3
   その他formed
4. 4
   その他The precipitates (triethylamine.HBr)
5. 5
   ろ過were filtered out
6. 6
   濃縮the filtrate was concentrated to dryness
7. 7
   その他Then the crude reaction mixture
8. 8
   その他was purified by column chromatography (SiO2, hexane/CH2Cl2=5/1)

実験手順

A mixture of 5-acenaphthylamine (1.0 g, 6 mmol) and triethylamine (0.76 g, 7.5 mmol) in toluene (50 mL) was stirred at 4° C., and 4-tert-butylbenzyl-bromide (1.36 g, 6 mmol) was added in slowly. The reaction mixture was stirred at 23° C. for 15 hours and precipitates formed. The precipitates (triethylamine.HBr) were filtered out; the filtrate was concentrated to dryness. Then the crude reaction mixture was purified by column chromatography (SiO2, hexane/CH2Cl2=5/1). N-(5-acenaphthyl)-4-tert-butylbenzylamine (1.67 g, an oil) was obtained.

出典