反応 #65274

反応方程式

methyl 3-(2-thienyl)heptanoate

ii

1-(2-chlorophenyl)methyl-5-carboxymethyl-2-propylthio-1H-imidazole

iii

E-3-[1-(2-chlorophenyl)methyl-2-propylthio-1H-imidazol-5-yl]-2-(2-thienyl)methyl-2-propenoic acid

iv

(E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-(4-pyridyl)-methyl-2-propenoic acid

→

title compound

(E)-3-[2-n-Butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-2-{1-(2-thienyl)pentyl}-2-propenoic Acid

反応条件

実験手順

The title compound was prepared using the procedure of Example 1 (i, ii, iii, iv [Method B]) replacing methyl 3-(2 -thienyl) propanoate with methyl 3-(2-thienyl)heptanoate; mp 161°-163° C.

出典