反応 #65249

反応方程式

2-n-butyl-1-(2-chlorophenyl)methyl-5-hydroxymethyl-1H-imidazole

→

2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-carboxaldehyde

収率 78.0%

溶媒

toluene

methylene chloride

反応条件

後処理

1. 1
   ろ過The solids were filtered
2. 2
   濃縮the filtrate concentrated
3. 3
   その他flash chromatographed over silica gel with 6:4 hexane/ethyl acetate

実験手順

A solution of 2-n-butyl-1-(2-chlorophenyl)methyl-5-hydroxymethyl-1H-imidazole (5.4 g, 0.0194 mol) in toluene (25 mL) was added to a suspension of activated manganese dioxide (27 g) in methylene chloride (325 mL). The suspension was stirred at room temperature for 17 hours. The solids were filtered and the filtrate concentrated and flash chromatographed over silica gel with 6:4 hexane/ethyl acetate to afford 4.16 g (78%) of 2-n-butyl-1-(2-chlorophenyl)methyl-1H-imidazol-5-carboxaldehyde, as an oil. NMR and IR were consistent with the structure.

出典