反応 #65206

反応方程式

6-(2-chlorobenzoyl)-5-(2-chlorobenzoylamino)indan

ammonia

→

5-amino-6-(2-chlorobenzoyl)indan

収率 94.4%

溶媒

H2SO4

—

ice water

反応条件

後処理

1. 1
   抽出extracted with ethyl acetate
2. 2
   洗浄The extract was washed with water
3. 3
   乾燥dried (MgSO4)
4. 4
   workup.DISTILLATIONthe solvent was distilled off

実験手順

A mixture of 6-(2-chlorobenzoyl)-5-(2-chlorobenzoylamino)indan (16.0 g) and 70% H2SO4 (100 ml) was heated at 120° C. for 30 minutes and, then, poured in ice-water (300 ml). The solution was alkalinized with concentrated aqueous ammonia and extracted with ethyl acetate. The extract was washed with water and dried (MgSO4) and the solvent was distilled off to give 5-amino-6-(2-chlorobenzoyl)indan as yellow oil (10.0 g, 94.3%). Recrystallization from hexane gave yellow prisms, m.p. 90°-92°.

出典