反応 #651876

ord-4ae6e98b334b4b1097edac165a9112b3

反応方程式

Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
olanzapine
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
cholesterol
O
water
→
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C.Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
Olanzapine Cholesterol

反応物

—
PVA
Cc1cc2c(s1)Nc1ccccc1N=C2N1CCN(C)CC1
olanzapine
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
cholesterol
—
polyvinyl alcohol
O
water
—
PVA

試薬

なし

溶媒

ClCCl
methylene chloride

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    workup.DISSOLUTIONdissolved
  2. 2
    workup.ADDITIONThe solution was poured into a square plastic container
  3. 3
    workup.STIRRINGstirred with an overhead stirrer at 450 RPM
  4. 4
    workup.STIRRINGthe mixture was stirred for 18 hours

実験手順

5 g (1%) polyvinyl alcohol (PVA) was added to 500 ml of deionized water. The solution was stirred with a magnetic stir bar and warmed for several hours until all of the PVA dissolved. The mixture was allowed to cool to room temperature. The solution was poured into a square plastic container and stirred with an overhead stirrer at 450 RPM. 1.2 g of olanzapine and 8.8 g of cholesterol was dissolved in 100 ml of methylene chloride. The PVA solution was added and the mixture was stirred for 18 hours.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06169084Auspto-grants-2001_01