反応 #65155

反応方程式

3-Chloropropylsulfonyl chloride

3-chloropropylsulfonyl chloride

O-benzylhydroxylamine hydrochloride

potassium carbonate

→

N-benzyloxy-3-chloropropylsulfonamide

収率 41.0%

溶媒

water

ether

反応条件

後処理

1. 1
   抽出the reaction mixture was extracted with ethyl acetate
2. 2
   洗浄From the fraction eluted with a mixture of ethyl acetate/n-hexane (1:4)

実験手順

3-Chloropropylsulfonyl chloride 1 (30.28 g,0.17 mol), O-benzylhydroxylamine hydrochloride (27.3 g,0.17 mol), potassium carbonate (50 g,0.36 mol) and tetrabutylammonium sulfate (about 500 mg) are reacted with each other in a mixture of ether and water (1:1) (100 ml) for 24 hours at room temperature and the reaction mixture was extracted with ethyl acetate. The extract was subjected to column chromatography on silica gel. From the fraction eluted with a mixture of ethyl acetate/n-hexane (1:4),18.4 g (41%) of crude N-benzyloxy-3-chloropropylsulfonamide (intermediate 3g) was obtained as a pale yellow oil.

出典