反応 #65128

反応方程式

2-Aminobenzenethiol

5-hydroxy-3-propylpyrimidine-2,4(1H,3H)-dione

N-bromosuccinimide

→

1,5-dihydro-3-propyl-2H-pyrimido[4,5-b][1,4]benzothiazine-2,4(3H)-dione

収率 87.3%

溶媒

ethanol

反応条件

後処理

1. 1
   温度the mixture was heated
2. 2
   温度at reflux for one hour
3. 3
   温度After cooling
4. 4
   その他the precipitate was collected

実験手順

To a solution of the 5-hydroxy-3-propylpyrimidine-2,4(1H,3H)-dione (0.85 g) in ethanol (40 ml), N-bromosuccinimide (0.98 g) was added in portions at room temperature. The mixture was stirred for 30 min. 2-Aminobenzenethiol (0.94 g) was added and the mixture was heated at reflux for one hour. After cooling, the precipitate was collected to give 1,5-dihydro-3-propyl-2H-pyrimido[4,5-b][1,4]benzothiazine-2,4(3H)-dione (1.20 g, 87% yield).

出典