反応 #65095

反応方程式

4-bromophenol

n-octylbromide

potassium carbonate

→

4-bromo-1-n-octyloxybenzene

収率 63.9%

溶媒

acetone

反応条件

後処理

1. 1
   温度to reflux for 12 hours
2. 2
   workup.DISTILLATIONAfter the solvent was distilled off under a reduced pressure
3. 3
   その他the residue thus obtained
4. 4
   抽出was extracted with isopropyl ether
5. 5
   洗浄washed with a 5% aqueous sodium hydroxide solution and water in turn
6. 6
   workup.DISTILLATIONThe ether was distilled off
7. 7
   その他the residue was purified by a silica gel column chromatography
8. 8
   workup.DISTILLATIONsubjected to distillation

実験手順

In 100 ml of acetone, 8.0 g of 4-bromophenol, 8.9 g of n-octylbromide, and 13 g of potassium carbonate were heated to reflux for 12 hours. After the solvent was distilled off under a reduced pressure, the residue thus obtained was extracted with isopropyl ether, washed with a 5% aqueous sodium hydroxide solution and water in turn. The ether was distilled off, and the residue was purified by a silica gel column chromatography using a mixed solvents of n-hexane and diethyl ether (10:1) and subjected to distillation to obtain 8.4 g of 4-bromo-1-n-octyloxybenzene.

出典