反応 #65037

反応方程式

1-[5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-2,2-di(phenylthio)-β-D-glycero-pentofuranosyl]uracil

azobisisobutylonitrile

→

1-[5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-2,2-di(phenylthio)-α-D-glycero-pentofuranosyl]uracil

溶媒

benzene

反応条件

後処理

1. 1
   その他To a solution prepared
2. 2
   workup.ADDITIONwere added
3. 3
   温度a reflux
4. 4
   温度under heating for 48 hours under an argon gas atmosphere
5. 5
   その他After completion of the reaction
6. 6
   その他a low boiling point substances were removed by distillation under a reduced pressure so as
7. 7
   その他to obtain a residue

実験手順

To a solution prepared by dissolving 7 mg (0.10 mmol) of 1-[5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-2,2-di(phenylthio)-β-D-glycero-pentofuranosyl]uracil prepared in step (3) in 10 ml of anhydrous benzene, 150 μl (0.57 mmol) of hydrogenated tributyl tin and 10 mg of azobisisobutylonitrile were added, followed by subjecting the resultant solution to a reflux under heating for 48 hours under an argon gas atmosphere. After completion of the reaction, a low boiling point substances were removed by distillation under a reduced pressure so as to obtain a residue.

出典