反応 #65016

反応方程式

NaOH

p-anisaldehyde

acetophenone

→

4'-methoxychalcone

収率 56.0%

溶媒

EtOH

water

反応条件

後処理

1. 1
   抽出extract with ether
2. 2
   洗浄wash with water and brine
3. 3
   乾燥dry over Na2SO4
4. 4
   濃縮concentrate to a solid
5. 5
   その他Recrystallize the solid from ether/hexanes

実験手順

Step A Add 10% aqueous NaOH (38 mL) to a solution of p-anisaldehyde (25 mL, 0.206 mol) and acetophenone (23.97 mL, 0.206 mol) in EtOH (500 mL). Stir the mixture at room temperature over night. Dilute the mixture with water and extract with ether. Combine the ethereal extracts, wash with water and brine, dry over Na2SO4 and concentrate to a solid. Recrystallize the solid from ether/hexanes to provide 27.51 g (56%) of 4'-methoxychalcone, mp 72°-74° C.

出典