反応 #64996

反応方程式

2-methyl-4-trifluoromethylthiazole-5-carboxylic chloride

trans-2-sec.-butylcyclohexylamine

triethylamine

→

2-methyl-4-trifluoromethyl-thiazole-5-carboxylic acid-trans-2-sec-butylcyclohexylamide

収率 44.6%

溶媒

tetrahydrofuran

water

反応条件

後処理

1. 1
   その他At 0° C.
2. 2
   抽出extracted twice with tert-butyl methyl ether
3. 3
   その他dried
4. 4
   その他the solvent is evaporated off

実験手順

At 0° C., 3.4 g of 2-methyl-4-trifluoromethylthiazole-5-carboxylic chloride is dripped into a solution of 2.3 g of trans-2-sec.-butylcyclohexylamine and 1.5 g of triethylamine in 15 ml of tetrahydrofuran, and the mixture is stirred for 2 hours at 25° C. The batch is diluted with 300 ml of water, extracted twice with tert-butyl methyl ether and dried, the solvent is evaporated off, and the residue is made into a paste with a small amount of pentane. There is isolated 2.3 g of 2-methyl-4-trifluoromethyl-thiazole-5-carboxylic acid-trans-2-sec-butylcyclohexylamide of m.p. 112°-113° C.

出典