反応 #64984

反応方程式

ethyl 2-(2,3,4,5,6-pentafluorobenzoyl)-3-(2,4-difluorophenylamino)acrylate

sodium fluoride

→

title compound

収率 94.6%

Ethyl 5,6,7,8-tetrafluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate

収率 94.6%

溶媒

dimethylformamide

反応条件

後処理

1. 1
   温度is heated at 140°-150° C. for 3 hours
2. 2
   ろ過the precipitate is filtered off with suction
3. 3
   洗浄washed with water
4. 4
   その他dried

実験手順

A mixture of 135.4 g of ethyl 2-(2,3,4,5,6-pentafluorobenzoyl)-3-(2,4-difluorophenylamino)acrylate, 20.6 g of sodium fluoride and 300 ml of anhydrous dimethylformamide is heated at 140°-150° C. for 3 hours. The suspension is poured hot onto 2 kg of ice and the precipitate is filtered off with suction, washed with water and dried. 122 g of the title compound of melting point 160°-162° C. are obtained.

出典