反応 #64983

反応方程式

2,4-difluoroaniline

ethyl 3-ethoxy-2-(2,3,4,5,6-pentafluorobenzoyl)-acrylate

water

→

title compound

収率 94.5%

Ethyl 2-(2,3,4,5,6-pentafluorobenzoyl)-3-(2,4-difluorophenylamino)-acrylate

収率 94.5%

溶媒

ethanol

反応条件

後処理

1. 1
   温度while cooling with ice
2. 2
   workup.STIRRINGThe mixture is stirred at room temperature for 1 hour
3. 3
   温度while cooling with ice
4. 4
   ろ過the precipitate is filtered off with suction
5. 5
   洗浄washed with ethanol/H2O (1:1)
6. 6
   その他dried

実験手順

44.3 g of 2,4-difluoroaniline are added dropwise to a solution of 115 g of ethyl 3-ethoxy-2-(2,3,4,5,6-pentafluorobenzoyl)-acrylate in 380 ml of ethanol, while cooling with ice and stirring. The mixture is stirred at room temperature for 1 hour, 380 ml of water are added, while cooling with ice, and the precipitate is filtered off with suction, washed with ethanol/H2O (1:1) and dried. 135.4 g of the title compound of melting point 97°-99° C. are obtained.

出典