反応 #64980

反応方程式

5-methyl-1,4-dihydropyridine-2,3dicarboxylic acid N-benzylimide

charcoal

→

5-Methyl-hexahydropyridine-2,3-dicarboxylic acid N-benzylimide

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   ろ過Then the catalyst is filtered off
2. 2
   濃縮the filtrate is concentrated by evaporation

実験手順

17.5 g (70 mmol) of 5-methyl-1,4-dihydropyridine-2,3dicarboxylic acid N-benzylimide are hydrogenated in 150 ml of tetrahydrofuran at 70° C. and under 100 bar over palladium on active charcoal. Then the catalyst is filtered off and the filtrate is concentrated by evaporation. The solid oily residue (13.0 g) is used as a crude product in the next stage.

出典