反応 #64957

反応方程式

trans-1-benzyl-3-benzylmethylamino-4-methoxy-pyrrolidine

hydrochloric acid

→

trans-4-Methoxy-3-methylamino-pyrrolidine dihydrochloride

溶媒

methanol

反応条件

後処理

1. 1
   ろ過The catalyst is filtered off with suction
2. 2
   濃縮the filtrate is concentrated
3. 3
   その他the residue is recrystallized from isopropanol/methanol

実験手順

9.3 g (29 mmol) of trans-1-benzyl-3-benzylmethylamino-4-methoxy-pyrrolidine are dissolved in 100 ml of methanol, 4.8 ml of concentrated hydrochloric acid are added and the mixture is hydrogenated on 4 g of 10% strength Pd-on-active charcoal at 90° C. under 100 bar. The catalyst is filtered off with suction, the filtrate is concentrated and the residue is recrystallized from isopropanol/methanol.

出典