反応 #64955

反応方程式

3-benzyl-6-oxa-3-azabicyclo[3.1.0]hexane

benzylmethylamine

→

trans-1-Benzyl-3-benzylmethylamino-4-hydroxypyrrolidine

溶媒

dioxane

water

反応条件

後処理

1. 1
   抽出The mixture is extracted with CHCl3
2. 2
   乾燥the extracts are dried with K2CO3
3. 3
   濃縮concentrated
4. 4
   workup.DISTILLATIONdistillation up to 160° C. (oil bath temperature)

実験手順

19.4 g (0.1 mol) of 90% strength 3-benzyl-6-oxa-3-azabicyclo[3.1.0]hexane are heated under reflux with 14.5 g (0.12 mol) of benzylmethylamine in 100 ml of dioxane and 200 ml of water overnight. The mixture is extracted with CHCl3, the extracts are dried with K2CO3 and concentrated and the residue is subjected to incipient distillation up to 160° C. (oil bath temperature).

出典