反応 #64935

反応方程式

1-benzyl-4-hydroxy-3-(2-hydroxyethylamino)-pyrrolidine

sodium hydroxide

→

8-Benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane

溶媒

sulphuric acid

water

反応条件

後処理

1. 1
   その他the sodium sulphate which has precipitated
2. 2
   ろ過is filtered off with suction
3. 3
   抽出the filtrate is extracted with chloroform
4. 4
   乾燥The extract is dried over potassium carbonate
5. 5
   濃縮concentrated
6. 6
   workup.DISTILLATIONthe residue is distilled

実験手順

15.6 g (66mmol) of 1-benzyl-4-hydroxy-3-(2-hydroxyethylamino)-pyrrolidine are heated under reflux in a mixture of 60 ml of concentrated sulphuric acid and 20 ml of water for 6 hours. The mixture is rendered alkaline with concentrated sodium hydroxide solution, the sodium sulphate which has precipitated is filtered off with suction and the filtrate is extracted with chloroform. The extract is dried over potassium carbonate and concentrated and the residue is distilled.

出典