反応 #649231

反応方程式

3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(3-formylphenyl)-1H-indole-7-carboxamide

(2R)-2-amino-3-methyl-1-butanol

NaBH(OAc)3

→

title compound

収率 32.5%

3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[3-({[(1R)-1-(hydroxymethyl)-2-methylpropyl]amino}methyl)phenyl]-1H-indole-7-carboxamide

収率 32.5%

反応条件

後処理

1. 1
   その他were reacted

実験手順

Following the general procedure of example 16, 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(3-formylphenyl)-1H-indole-7-carboxamide (50 mg, 0.114 mmol), (2R)-2-amino-3-methyl-1-butanol (10.2 mg, 0.087 mmol) and NaBH(OAc)3 (58 mg, 0.261 mmol) were reacted to give the title compound (14.9 mg, 25%).

出典