反応 #64903

反応方程式

Phosphorous oxychloride

sodium hydroxide

5-aminoacenaphthene

sodium nitromalondialdehyde monohydrate

aniline hydrochloride

→

8-Nitro-10-azaacephenanthrene

溶媒

acetic acid

反応条件

後処理

1. 1
   workup.STIRRINGThis mixture was stirred for 10 min
2. 2
   温度heated
3. 3
   温度at reflux for 2 h
4. 4
   温度heating
5. 5
   workup.WAITwas continued for 3 h
6. 6
   温度The resulting mixture was cooled to room temperature
7. 7
   抽出extracted with dichloromethane
8. 8
   乾燥The extracts were dried over sodium sulfate and condensed to dryness
9. 9
   その他The condensed product was purified
10. 10
    その他to obtain a fluffy, bright yellow solid, 3.20 g (43%)

実験手順

A mixture of 5-aminoacenaphthene (Grabe, C. Liebigs Ann. der Chemie 1903, 327, 77) (5.0 g, 29.5 mmol) and sodium nitromalondialdehyde monohydrate (Fanta, P. E. Org. Syntheses Coll. vol. 4 1963, 844) (5.51 g, 35 mmol) in acetic acid (140 mL) was stirred for 1 h at room temperature and aniline hydrochloride (5.21 g, 40.2 mmol) was added. This mixture was stirred for 10 min and heated at reflux for 2 h. Phosphorous oxychloride (3 mL, 32.2 mmol) was added and heating was continued for 3 h. The resulting mixture was cooled to room temperature and poured into ice/water (200 mL). The aqueous mixture was neutralized with 2M sodium hydroxide solution and extracted with dichloromethane. The extracts were dried over sodium sulfate and condensed to dryness. The condensed product was purified using flash chromatography (20% hexane/dichloromethane, silica gel) to obtain a fluffy, bright yellow solid, 3.20 g (43%): MS m/e 251 (M+H +); 1H NMR (CD2C12, 300 MHz) δ 3.48-3.55 (m, 4H), 7.56 (s, 1H), 7.68 (d, J=7.0 Hz, 1H), 7.77 (t, J=7.8 Hz, 1H), 8.79 (d, J=8.1 Hz, 1H), 8.94 (d, J=2.5 Hz, 1H), 9.65 (d, J=2.5 Hz, 1H).

出典