反応 #64890

反応方程式

Trichloroethyl chloroformate

9,10-dihydro-10-methyl-9-(1-methyl-4-piperidinyl)acridine

triethylamine

→

crude product

4-(9,10-DIHYDRO-10-METHYL-9-ACRIDINYL)-1-(2,2,2-TRICHLOROETHYLOXYCARBONYL)PIPERIDINE

溶媒

toluene

反応条件

後処理

1. 1
   抽出by extracting with EtOAc
2. 2
   洗浄washing with a 10% NaOH solution

実験手順

Trichloroethyl chloroformate (1.06 mL, 7.7 mmol) is added over a 10 minute period to a solution of 9,10-dihydro-10-methyl-9-(1-methyl-4-piperidinyl)acridine (453 mg, 1.55 mmol) [(Tetrahedron Letters, 29, 5701 (1988)] and triethylamine (649 μl, 4.65 mmol) in 20 mL of dry toluene at 85° C. The reaction is worked up after 30 minutes by extracting with EtOAc and washing with a 10% NaOH solution. The crude product is obtained after the solvent is removed.

出典