反応 #64883

反応方程式

thionyl chloride

α-(2-methoxymethylphenyl)-β-methylacrylic acid

pyridine

→

title compound

収率 96.5%

α-(2-methoxymethylphenyl)-β-methylacrylic chloride

収率 96.5%

溶媒

ether

反応条件

後処理

1. 1
   その他At 0° to 5° C.
2. 2
   ろ過After filtration
3. 3
   洗浄the residue was washed with diethyl ether
4. 4
   その他After removal of the solvent

実験手順

At 0° to 5° C., 3.7 g of thionyl chloride was dripped into 4.9 g (24 mmol) of α-(2-methoxymethylphenyl)-β-methylacrylic acid and 2.5 g of pyridine in 40 ml of ether. The mixture was stirred for 3 hours at about 20° C. After filtration, the residue was washed with diethyl ether. The filtrate was combined with the ether phase. After removal of the solvent, there was obtained 5.2 g (96.5%) of the title compound as a colorless oil. The crude product can be used for further reactions without any additional purification.

出典