反応 #648685

反応方程式

2-bromo-5-fluorotoluene

4-chloro-2-fluorobenzaldehyde

compound

(4-Chlorophenyl)(4-methoxyphenyl)methanol

→

title compound

(4-Chloro-2-fluorophenyl)(4-fluoro-2-methylphenyl)methanol

反応条件

後処理

1. 1
   その他The title compound was prepared
2. 2
   その他was purified twice by preparative HPLC

実験手順

The title compound was prepared starting from 5.00 g (26.45 mmol) of 2-bromo-5-fluorotoluene and 5.03 g (31.74 mmol) of 4-chloro-2-fluorobenzaldehyde in analogy to the synthesis of the compound from Example 175A. A difference was that the crude product was purified twice by preparative HPLC. 4.84 g (65% of theory) of the title compound were obtained.

出典