反応 #6482

反応方程式

potassium hydroxide

phenylacetaldehyde

1,3-propanedithiol

boron trifluoride etherate

→

title compound

収率 91.0%

2-Phenylmethyl-1,3-dithiane

収率 91.0%

溶媒

methylene chloride

反応条件

後処理

1. 1
   その他The layers were separated
2. 2
   抽出the aqueous layer was extracted with methylene chloride
3. 3
   抽出The combined organic extract
4. 4
   洗浄was washed with 1N aqueous sodium hydroxide solution and brine
5. 5
   乾燥dried over anhydrous magnesium sulfate
6. 6
   ろ過filtered
7. 7
   workup.DISTILLATIONthe filtrate was distilled

実験手順

To a solution of 33.9 g (280 mmol) of phenylacetaldehyde and 35.6 g (330 mmol) of 1,3-propanedithiol in 300 mL of methylene chloride at 0° C., was added, dropwise over a period of 30 minutes, 10 mL of boron trifluoride etherate. The reaction mixture was allowed to warm to ambient temperature and stirred for 3 h at ambient temperature. The reaction mixture was made basic by the addition of 180 mL of 5% aqueous potassium hydroxide solution and the resultant mixture was stirred for 0.5 h. The layers were separated and the aqueous layer was extracted with methylene chloride. The combined organic extract was washed with 1N aqueous sodium hydroxide solution and brine, dried over anhydrous magnesium sulfate, filtered and the filtrate was distilled to afford 53.62 g (91% yield) of the title compound, b.p. 150° C. (2 mm Hg); 1H NMR (CDCl3) δ1.75-1.95 (1H, m), 2.05-2.17 (1H, m), 2.75-2.91 (4H, m), 3.03 (2H, d, J=9 Hz), 4.25 (1H, t, J=9 Hz), 7.17-7.38 (5H, m).

出典