反応 #64751

反応方程式

hydrogen

pyrimidinone

5-[3-(bicyclo[2.2.1]hept-2-yloxy)-4-methoxyphenyl]-1,2-dihydro-2-pyrimidinone

→

dihydro pyrimidinone

収率 31.8%

5-[3-(Bicyclo[2.2.1]hept-2-yloxy)-4-Methoxyphenyl]-1,2,3,4-Tetrahydro-2-Pyrimidinone

収率 31.8%

溶媒

ethanol

反応条件

後処理

1. 1
   温度refluxed for 18 hours
2. 2
   温度The reaction is cooled
3. 3
   ろ過filtered through celite
4. 4
   濃縮the filtrate concentrated in vacuo
5. 5
   その他The residue is crystallized from ethyl acetate

実験手順

The pyrimidinone (0.38 g, 1.22 mmol) is dissolved in 20 ml ethanol and treated with 0.5 g Raney Nickel, 40 psi hydrogen and refluxed for 18 hours. The reaction is cooled, filtered through celite, and the filtrate concentrated in vacuo. The residue is crystallized from ethyl acetate to afford 0.12 g (31.8%) of the dihydro pyrimidinone as a crystalline solid comprising a 7:3 mixture of endo/exo norbornyl isomers.

出典