反応 #64717

反応方程式

hydrogencarbonate

methanol

Compound 2

2-[Bis(4-acetoxyphenyl)methyl]-N-(2,4-dimethoxyphenyl)benzamide

→

desired product

収率 56.0%

2-[Bis(4-hydroxyphenyl)methyl]-N-(2,4-dimethoxyphenyl)benzamide

収率 56.0%

溶媒

sodium

反応条件

後処理

1. 1
   温度the suspension was heated
2. 2
   温度under reflux for 30 minutes
3. 3
   濃縮The resulting mixture was concentrated under reduced pressure, and water
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   抽出The resulting mixture was extracted with ethyl acetate
6. 6
   乾燥the extract was dried over anhydrous magnesium sulfate
7. 7
   濃縮After concentration under reduced pressure
8. 8
   その他the residue was recrystallized

実験手順

In a mixture of 50 ml of saturated aqueous sodium. hydrogencarbonate solution and 50 ml of methanol was suspended 2.6 g of Compound 2 prepared in Example 1, and the suspension was heated under reflux for 30 minutes. The resulting mixture was concentrated under reduced pressure, and water was added to the residue. The resulting mixture was extracted with ethyl acetate, and the extract was dried over anhydrous magnesium sulfate. After concentration under reduced pressure, the residue was recrystallized to afford 1.23 g of the desired product.

出典