反応 #64706

反応方程式

Methyl isocyanide

2-methylbenzoyl chloride

hydrochloric acid

acetone

→

title compound

N-methyl-2-(2-tolyl)-2-oxoacetamide

溶媒

water

反応条件

後処理

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature for 1.5 hours for hydrolysis
2. 2
   抽出The mixture was extracted with methylene chloride
3. 3
   洗浄washed with water
4. 4
   その他dried
5. 5
   その他The solvent was evaporated under reduced pressure

実験手順

Methyl isocyanide (0.84 ml) was added to 2-methylbenzoyl chloride (1.55 g). The mixture was stirred at 60° C. for 16 hours. Then, 5N hydrochloric acid (1.5 ml) and acetone (2 ml) were added, and the mixture was stirred at room temperature for 1.5 hours for hydrolysis. Then, water was added. The mixture was extracted with methylene chloride, washed with water and dried. The solvent was evaporated under reduced pressure to obtain the title compound as an oil (1.68 g).

出典