反応 #64689

反応方程式

5-(3,4-dimethoxyphenylmethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione

formic acid

triethylamine

hydrochloric acid

→

3-(3,4-dimethoxyphenyl)propionic acid

溶媒

chloroform

water

反応条件

後処理

1. 1
   その他prepared
2. 2
   温度cooled down
3. 3
   その他After separation the chloroform phase
4. 4
   その他was evaporated under reduced pressure
5. 5
   その他to give a white crystalline product

実験手順

After adding 2.5 ml of the mixture of formic acid and triethylamine prepared according to Example 1 to 2.94 g (0.01 mol) of 5-(3,4-dimethoxyphenylmethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (m.p.: 142°-144° C.), the reaction mixture was heated to 100° C. for 2 hours, then cooled down. After the addition of 25 ml of water the pH value was adjusted to 1 by adding concentrated hydrochloric acid, then the mixture was thoroughly shaken with 100 ml of chloroform. After separation the chloroform phase was evaporated under reduced pressure to give a white crystalline product.

出典