反応 #64667

反応方程式

2-ethoxyphenyl N-(2-ethoxyphenoxysulfonyl)carbamate

2-amino-4,6-dimethoxypyrimidine

→

desired product

収率 97.5%

1-(2-Ethoxyphenoxysulfonyl)-3-(4,6-dimethoxy-2-pyrimidyl)urea

収率 97.5%

溶媒

toluene

反応条件

後処理

1. 1
   温度After cooling to 30° C.
2. 2
   ろ過the precipitate is filtered off
3. 3
   洗浄washed with 100 ml of toluene

実験手順

38.1 g of 2-ethoxyphenyl N-(2-ethoxyphenoxysulfonyl)carbamate are dissolved in 500 ml of toluene, 15.5 g of 2-amino-4,6-dimethoxypyrimidine are added at room temperature, and the mixture is heated for 2 hours at 100° C. After cooling to 30° C., the precipitate is filtered off and washed with 100 ml of toluene. 38.8 g of the desired product are obtained with a purity of 98.8%, corresponding to a yield of 96.4% of theory. The melting point for the product is 147°-149° C. 6.5 g of 2-ethoxyphenol are recovered from the mother liquor by distillation.

出典