反応 #64594

反応方程式

Glycine

Triethylamine

1-bromododecane

→

N-n-dodecylglycine

収率 26.3%

溶媒

IPA

water

反応条件

後処理

1. 1
   その他After the solvent was removed
2. 2
   workup.ADDITIONTHF was added to the remaining material
3. 3
   その他Triethylamine hydrobromide was removed by filtration
4. 4
   濃縮the filtrate was concentrated

実験手順

Glycine was dissolved in a 2:1 mixture by volume of IPA and water. Triethylamine and 1-bromododecane were added to the solution successively and the mixture was kept stirring for more than 7 days. After the solvent was removed, THF was added to the remaining material. Triethylamine hydrobromide was removed by filtration and the filtrate was concentrated. N-n-dodecylglycine was obtained from the concentrated solution by separation and purification by column chromatography with the yield of 26.3%.

出典