反応 #64590

反応方程式

hydrochloric acid

chloride

THF

Anthranilic acid

pyridine

tetrahydrofuran

→

N-n-octanoylanthranilic acid

収率 79.4%

反応条件

後処理

1. 1
   workup.ADDITIONwas added to the reaction mixture
2. 2
   ろ過Pyridine hydrochloride was filtered
3. 3
   その他the solvent was removed

実験手順

Anthranilic acid was dissolved in a mixed solvent containing pyridine and tetrahydrofuran (THF) in 5:5 ratio and a THF solution of n-caprioyl chloride was dropped to the solution during several hours for reaction. After the reaction, hydrochloric acid was added to the reaction mixture. Pyridine hydrochloride was filtered and the solvent was removed. N-n-octanoylanthranilic acid was obtained from the remaining reactant after the purification by column chromatography with the yield of 79.4%.

出典