反応 #64493

反応方程式

5-n-butyl-2,4-dihydro-4-[[2'-(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]-3H-1,2,4-triazol-3-one

5-n-Butyl-2,4-dihydro-4-[[2'-(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]-3H-1,2,4-triazol-3-one

1-bromo-1-phenylpropane

→

desired material

収率 50.0%

5-n-Butyl-2,4-dihydro-2-(1-phenylpropyl)-4-[[2'-(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]-3H-1,2,4-triazol-3-one

収率 50.0%

反応条件

後処理

1. 1
   その他chromatographed over silica gel (gradient elution using 0.2-1.0% MeOH/CH2Cl2)

実験手順

The alkylation of 5-n-butyl-2,4-dihydro-4-[[2'-(N-trityltetrazol-5-yl)biphenyl-4-yl]methyl]-3H-1,2,4-triazol-3-one (from Example 2, Step D) with 1-bromo-1-phenylpropane was carried out as described in Example 3, Step A. After work-up, the residue was flash chromatographed over silica gel (gradient elution using 0.2-1.0% MeOH/CH2Cl2) to give the desired material in 50% yield, homogeneous by TLC in 2% MeOH/CH2Cl2, mass spectrum (FAB) 736 (M+1)+.

出典