反応 #644451

反応方程式

water

sodium 3-(4-(pyridin-2-yloxymethyl)-phenyl)-oxiran-2-carboxylate

acetic acid

toluene

→

title compound

(4-(Pyridin-2-yloxymethyl)-phenyl)-acetaldehyde

溶媒

ethyl acetate

反応条件

後処理

1. 1
   その他was allowed to room temperature, to the reaction mixture
2. 2
   抽出extracted
3. 3
   その他the organic layer was separated
4. 4
   洗浄washed with saturated sodium chloride water
5. 5
   乾燥dried over anhydrous magnesium sulfate
6. 6
   その他The solvent thereof was evaporated under a reduced pressure

実験手順

A mixture of sodium 3-(4-(pyridin-2-yloxymethyl)-phenyl)-oxiran-2-carboxylate described in Preparation Example 2-1-2 (9.95 g), toluene (200 mL), water (120 mL) and acetic acid (16 mL) was stirred at 73° C for 90 minutes. The reaction mixture was allowed to room temperature, to the reaction mixture was added ethyl acetate, and extracted, and then the organic layer was separated, washed with saturated sodium chloride water, and dried over anhydrous magnesium sulfate. The solvent thereof was evaporated under a reduced pressure to obtain the title compound (6.82 g).

出典