反応 #644450

反応方程式

methyl 3-(4-(pyridin-2-yloxymethyl)-phenyl)-oxiran-2-carboxylate

water

ethanol

sodium methoxide

→

title compound

Sodium 3-(4-(pyridin-2-yloxymethyl)-phenyl)-oxiran-2-carboxylate

溶媒

diethyl ether

tetrahydrofuran

反応条件

後処理

1. 1
   その他at 0° C
2. 2
   ろ過the precipitated solids were filtered

実験手順

To a mixture of methyl 3-(4-(pyridin-2-yloxymethyl)-phenyl)-oxiran-2-carboxylate described in Preparation Example 2-1-1 (19.9 g) and ethanol (300 mL) were sequentially added sodium methoxide (14.2 mL, 28% methanol solution), water (1.3 mL), tetrahydrofuran (100 mL) at 0° C, which was stirred at room temperature for one hour. To the reaction mixture was added diethyl ether (200 mL), and the precipitated solids were filtered to obtain the title compound (14.3 g).

出典