反応 #644442

反応方程式

(4-(pyridin-2-yloxymethyl)-phenyl)methanol

→

title compound

4-(Pyridin-2-yloxymethyl)-benzaldehyde

溶媒

methylene chloride

反応条件

後処理

1. 1
   ろ過The reaction mixture was filtered through a celite bed
2. 2
   その他the solvent thereof was evaporated under a reduced pressure
3. 3
   その他The residue was purified by silica gel column chromatography (ethyl acetate:heptane=1:4)

実験手順

To a mixture of (4-(pyridin-2-yloxymethyl)-phenyl)methanol described in Preparation Example 1-3-1 (1.9 g, 8.6 mmol) and methylene chloride (30 mL) was added manganese dioxide (15 g, 17 mmol) at room temperature, which was stirred overnight at this temperature. The reaction mixture was filtered through a celite bed, and the solvent thereof was evaporated under a reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:heptane=1:4) to obtain the title compound (770 mg).

出典